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Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined. [2]
In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands ...
HG is estimated to affect 0.3–2.0% of pregnant women, although some sources say the figure can be as high as 3%. [6] [9] [5] While previously known as a common cause of death in pregnancy, with proper treatment this is now very rare. [13] [14] Those affected have a lower risk of miscarriage but a higher risk of premature birth. [15]
The drug was withdrawn from world market when it became evident that the use in pregnancy causes phocomelia (clinical conditions where babies are born with deformed hand and limbs). Later in late 1970s studies indicated that the (R)- enantiomer is an effective sedative, the (S)-enantiomer harbors teratogenic effect and causes fetal abnormalities.
The 17-year-old went viral for firing a bullseye during the 1/8 elimination round of the women’s individual compound open competition. ... Devi was born with phocomelia, ...
Men (and women) can go bald for several different reasons. Genetics are a major cause, while stress, diet, lifestyle choices, certain medications and age can also cause people to experience hair loss.
Queen Elizabeth I’s reign was defined by power, strategy and an ironclad reputation — but one scandal threatened to shake the foundation of her carefully crafted image.
external causes during pregnancy (thus not inherited), e.g. via amniotic band syndrome; teratogenic drugs (e.g. thalidomide, which causes phocomelia) or environmental chemicals; ionizing radiation (nuclear weapons, radioiodine, radiation therapy) infections; metabolic imbalance