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Chronic intestinal pseudo-obstruction (CIPO) is a very rare syndrome with chronic and recurrent symptoms that suggest intestinal obstruction in the absence of any mechanical blockage of the lumen. [3] The most common symptoms of CIPO include abdominal pain, constipation, nausea, vomiting, dysphagia, and abdominal distention.
Bowel obstruction, also known as intestinal obstruction, is a mechanical or functional obstruction of the intestines which prevents the normal movement of the products of digestion. [2] [5] Either the small bowel or large bowel may be affected. [1] Signs and symptoms include abdominal pain, vomiting, bloating and not passing gas. [1]
The narrow mesentery predisposes some cases of malrotation to midgut volvulus, a twisting of the entire small bowel that can obstruct the mesenteric blood vessels leading to intestinal ischemia, necrosis, and death if not promptly treated. The fibrous Ladd's bands can constrict the duodenum, leading to intestinal obstruction.
An inherited form – familial multiple intestinal atresia – has also been described. This disorder was first reported in 1971. [4] It is due to a mutation in the gene TTC7A on short arm of chromosome 2 (2p16). It is inherited as an autosomal recessive gene and is usually fatal in infancy. Ileal atresia can also result as a complication of ...
Complications may include enterocolitis, megacolon, bowel obstruction and intestinal perforation. [1] [2] The disorder may occur by itself or in association with other genetic disorders such as Down syndrome or Waardenburg syndrome. [1] [2] About half of isolated cases are linked to a specific genetic mutation, and about 20% occur within ...
Intestinal pseudo-obstruction (IPO) is a clinical syndrome caused by severe impairment in the ability of the intestines to push food through. It is characterized by the signs and symptoms of intestinal obstruction without any lesion in the intestinal lumen. [ 1 ]
Mungan syndrome [1] was first described in 2003 by Z. Mungan et al. [2] as an autosomal recessively inherited disorder in a Turkish family. It is characterized by mainly gastrointestinal hypomotility related to visceral neuromyopathy which cause chronic intestinal pseudo-obstruction (CIIP).
Causes of constipation may include faecal impaction and bowel obstruction, which may in turn be caused by ileus, intussusception, volvulus. Inflammatory bowel disease is a condition of unknown aetiology, classified as either Crohn's disease or ulcerative colitis , that can affect the intestines and other parts of the gastrointestinal tract.
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