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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4][6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
Side effects. The common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. [10][11] Bupropion has the highest incidence of insomnia of all second-generation antidepressants, apart from desvenlafaxine. [93]
Serotonin–norepinephrine reuptake inhibitors include: Desvenlafaxine (Pristiq) Duloxetine (Cymbalta) Levomilnacipran (Fetzima) Milnacipran (Ixel, Savella, Milnaneurax) Venlafaxine (Effexor, Trevilor) Serotonin–dopamine reuptake inhibitor (SDRIs) Serotonin–dopamine reuptake inhibitors include: None currently marketed.
The FDA in 2014 approved Contrave tablets as a weight loss treatment featuring naltrexone (an opioid antagonist) and bupropion (an antidepressant) as active ingredients.
In Wikidata. Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into ...
This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder , treatment-resistant depression , dysthymia , bipolar depression , and postpartum depression , among others.
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