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Adapted from Ellis, Frank (2002) Paracetamol: a curriculum resource, Cambridge: Royal Society of Chemistry ISBN: 0-85404-375-6. Author: WhiteTimberwolf, PNG version: Rifleman 82: Permission (Reusing this file)
Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.
English: The direct, one-pot synthesis of paracetamol from hydroquinone and ammonium acetate as described in Green Chem., 2014,16, 2997-3002 Date 31 January 2021
An industrial synthesis of paracetamol developed by Hoechst–Celanese involves the conversion of a methyl ketone to an acetanilide via a Beckmann rearrangement. [ 15 ] The thermal rearrangement that occurs in the synthesis of ketamine was claimed to be a Beckmann rearrangement according to: url .
Prominently, it is the final intermediate in the industrial synthesis of paracetamol. Treating 4-aminophenol with acetic anhydride gives paracetamol: [8] [9] [10] It is a precursor to amodiaquine, mesalazine, AM404, parapropamol, B-86810 & B-87836 (c.f. WO 2001042204 ). 4-Aminophenol converts readily to the diazonium salt. [11]
Metacetamol (developmental code name BS-749), also known as 3-hydroxyacetanilide and AMAP, is a non-toxic regioisomer of paracetamol with analgesic and antipyretic properties, but has never been marketed as a drug. [1] [2] Metacetamol is known to have several polymorphs. [3] Form II is metastable, while form I is stable. [3]
Organic synthesis is a special type of chemical synthesis dealing with the synthesis of organic compounds. For the total synthesis of a complex product, multiple procedures in sequence may be required to synthesize the product of interest, needing a lot of time. A purely synthetic chemical synthesis begins with basic lab compounds.
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