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The general structure of a hydroxamic acid. In organic chemistry, hydroxamic acids are a class of organic compounds having a general formula R−C(=O)−N(−OH)−R' bearing the functional group −C(=O)−N(−OH)−, where R and R' are typically organyl groups (e.g., alkyl or aryl) or hydrogen.
The Angeli–Rimini reaction is an organic reaction between an aldehyde and N-hydroxybenzenesulfonamide in presence of base forming a hydroxamic acid. The Angeli-Rimini reaction. The other reaction product is a sulfinic acid. The reaction was discovered by the two Italian chemists Angelo Angeli and Enrico Rimini (1874–1917), and was published ...
Hadacidin is the simplest known naturally occurring hydroxamic acid. The hydroxylamino group is frequently donated by a hydroxylamino acid such as 8-N-hydroxyornithine of the siderochromes. This compound, first isolated and characterized by Kaczka et al. in 1962, [2] seemed well suited for a study of the route of hydroxamic acid biosynthesis.
The mechanism below begins with an O-acylated hydroxamic acid derivative that is treated with base to form an isocyanate that generates an amine and CO 2 gas in the presence of H 2 O. The hydroxamic acid derivative is first converted to its conjugate base by abstraction of a hydrogen by a base.
An ester of a carboxylic acid.R stands for any group (typically hydrogen or organyl) and R ′ stands for any organyl group.. In chemistry, an ester is a compound derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group (−OH) of that acid is replaced by an organyl group (R ′). [1]
Hydroxylammonium chloride is a chemical compound with the formula [NH 3 OH] + Cl −.It is the hydrochloric acid salt of hydroxylamine (NH 2 OH).Hydroxylamine is a biological intermediate in nitrification (biological oxidation of ammonia with oxygen into nitrite) and in anammox (biological oxidation of nitrite and ammonium into dinitrogen gas) which are important in the nitrogen cycle in soil ...
Salicylhydroxamic acid (SHA or SHAM) is a drug that is a potent and irreversible enzyme inhibitor of the urease enzyme in various bacteria and plants; it is usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by urease; [ 1 ] it thus disrupts the bacteria's metabolism through competitive inhibition .
In addition, 2-nitrophenylacetic acid is a precursor for many heterocycles. Complete reduction of 2-nitrophenylacetic acid yields anilines, which quickly cyclize to form lactams. [7] [8] Partial reductive cyclization of the acids using weaker reducing agents forms hydroxamic acids. [8]