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Animal testing, also known as animal experimentation, animal research, and in vivo testing, is the use of non-human animals, such as model organisms, in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in ...
Fortrea primate-testing lab, Vienna, Virginia, 2004–05. Most of the NHPs used are one of three species of macaques, accounting for 79% of all primates used in research in the UK, and 63% of all federally funded research grants for projects using primates in the U.S. [25] Lesser numbers of marmosets, tamarins, spider monkeys, owl monkeys, vervet monkeys, squirrel monkeys, and baboons are used ...
Today, these three principles are central to the laws and guidelines governing the use of animals and research. In the U.S., the Animal Welfare Act of 1970 (see also Laboratory Animal Welfare Act) set standards for animal use and care in research. This law is enforced by APHIS's Animal Care program. [131] In academic settings in which NIH ...
Understanding Animal Research (UAR) is a British membership organisation formed in late 2008 through the merger of the Research Defence Society and the Coalition for Medical Progress. Its main aims are to "explain why animals are used in medical and scientific research.
Different non-human animals unwillingly help humans with creating medicine that can treat certain human diseases. For example, the anticoagulant properties of snake venom are key to potential medical use. These toxins can be used to treat heart disease, pulmonary embolism, and many other diseases, all of which may originate from blood clots.
Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. [ 33 ] [ 34 ] Researchers have also noted that many studies involving mice, rats and other rodents are poorly designed, leading to questionable findings.
Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. [ 2 ] A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context ...
Comparative medicine is a distinct discipline of experimental medicine that uses animal models of human and animal disease in translational and biomedical research. [1]: 2 [2] In other words, it relates and leverages biological similarities and differences among species to better understand the mechanism of human and animal disease.