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The Zydis formulations consist of a drug physically trapped in a water-soluble matrix (saccharine mixture and polymer), which is freeze dried to produce a product that dissolves rapidly when placed in mouth. The ideal candidate for Zydis technology should be chemically stable and insoluble and particle size preferably less than 50 micron.
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. [1] It is generally used for mildly to moderately severe disease. [ 1 ]
The following chart shows the solubility of various ionic compounds in water at 1 atm pressure and room temperature (approx. 25 °C, 298.15 K). "Soluble" means the ionic compound doesn't precipitate, while "slightly soluble" and "insoluble" mean that a solid will precipitate; "slightly soluble" compounds like calcium sulfate may require heat to precipitate.
In December 2016, Zydus Discovery DMCC, a research subsidiary Zydus Lifesciences, was cited by the US FDA for deliberately misbranding their flagship product, Saroglitazar—the drug used to treat diabetic dyslipidemia in India. In a 21 December 2016 letter to the company, the US FDA asked it to stop using broad statements, such as the "world's ...
The following compounds are liquid at room temperature and are completely miscible with water; ... furfuryl alcohol: 98-00-0 C 3 H 8 O 3: glycerol: 56-81-5 CH 3 OH ...
A cosolvent miscible in both phases and able to dissolve the solute is added to form a homogeneous solution of water, organic solvent, and compound (right). In chemistry, cosolvents are substances added to a primary solvent in small amounts to increase the solubility of a poorly-soluble compound.
Some alkaloids are more stable as ionic salts than as free base. The salts usually exhibit greater water solubility. Common counterions include chloride, bromide, sulfate, phosphate, nitrate, acetate, oxalate, citrate, and tartrate. Ammonium salts formed from the acid–base reaction with hydrochloric acid are known as hydrochlorides.
Balsalazide is an anti-inflammatory drug used in the treatment of inflammatory bowel disease. It is sold under the brand names Giazo, Colazal in the US and Colazide in the UK. It is also sold in generic form in the US by several generic manufacturers. It is usually administered as the disodium salt.
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related to: zydus mesalamine vs lialda and alcohol based water soluble pills treatment- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
