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The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as bisphosphonate-related osteonecrosis of the jaw ( BON or BRONJ ) because osteonecrosis of the jaw correlating with bisphosphonate treatment was frequently encountered, with its first incident occurring in 2003.
Osteoradionecrosis (ORN) is a serious complication of radiation therapy in cancer treatment where radiated bone becomes necrotic and exposed. [1] ORN occurs most commonly in the mouth during the treatment of head and neck cancer, and can arise over 5 years after radiation. [2]
Post radiation maxillary bone osteonecrosis is something that is found more in the lower jaw (mandible) rather than the maxilla (upper jaw) this is because there are many more blood vessels in the upper jaw. [7] The symptoms of this are very similar to the symptoms of medication-related osteonecrosis of the jaw (MRONJ). Patients are in a lot of ...
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
While DNA damage happens frequently and naturally in the cell from endogenous sources, clustered damage is a unique effect of radiation exposure. [41] Clustered damage takes longer to repair than isolated breakages, and is less likely to be repaired at all. [42] Larger radiation doses are more prone to cause tighter clustering of damage, and ...
Radium can cause fatal injuries due to radium and calcium sharing similar chemistry, causing the body to unintentionally incorporate the radioactive metal into bone tissue in place of calcium. This is significant, because while calcium strengthens bone structures, radium degrades the quality of said bone structure.
Methamphetamine users sometimes experience soreness in the joint of the jaw and dental attrition (tooth wear) due to bruxism, a common side effect of stimulant drugs. [5] This bruxism can occur continuously. [7] Chronic use of the drug might also cause trismus, the inability to open the jaw. [8]
The company promised radiantly white teeth and bacterial extraction due to the ionizing radiation of the radioactive substances. The toothpaste was considered at the time a milestone of technical achievement and was touted as a "miracle remedy". Consequential damage caused by ionizing radiation is mostly unknown.