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2. Fecal impaction - Wikipedia

   en.wikipedia.org/wiki/Fecal_impaction

   Osmotic laxatives such as magnesium citrate work within minutes to eight hours for onset of action, and even then they may not be sufficient to expel the stool. [citation needed] Osmotic laxatives can cause cramping and even severe pain as the patient's attempts to evacuate the contents of the rectum are blocked by the fecal mass.

3. Methylnaltrexone - Wikipedia

   en.wikipedia.org/wiki/Methylnaltrexone

   Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.

4. Constipation - Wikipedia

   en.wikipedia.org/wiki/Constipation

   Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. [2] The stool is often hard and dry. [4] Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. [3]

5. Laxative - Wikipedia

   en.wikipedia.org/wiki/Laxative

   Bulk-forming laxatives, also known as roughage, are substances, such as fiber in food and hydrophilic agents in over-the-counter drugs, that add bulk and water to stools so they can pass more easily through the intestines (lower part of the digestive tract). [2] Properties. Site of action: small and large intestines; Onset of action: 12–72 hours

6. Are laxatives for weight loss safe? - AOL

   www.aol.com/laxatives-weight-loss-safe-153000701...

   Long-term laxative abuse can create potassium deficiencies, kidney damage, and heart problems that can become dangerous and significantly damage the body. Taking laxatives for weight loss is on ...

7. With laxatives in high demand, doctors warn not to take them ...

   www.aol.com/news/laxatives-high-demand-doctors...

   People taking laxatives who experience sudden weight loss, blood in their stool or constipation lasting more than three months should see a doctor, said Dr. Satish Rao, a professor of medicine at ...