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1-Ethynylcyclohexanol (ECX) is an alkynyl alcohol derivative which is both a synthetic precursor to, and an active metabolite of the tranquilizer ethinamate, and has similar sedative, anticonvulsant and muscle relaxant effects. It has been sold as a designer drug, first being identified in the UK in March 2012. [1] [2] [3] [4]
Ethinamate (1-ethynylcyclohexanone carbamate) is synthesized by combining acetylene with cyclohexanone to make 1-ethynylcyclohexanol, and then transforming this into a carbamate by the subsequent reaction with phosgene, and later with ammonia. Some lithium metal or similar is used to make the acetylene react with the cyclohexanone in the first ...
The Glaser coupling is a type of coupling reaction. It is by far one of the oldest coupling reactions and is based on copper compounds like copper(I) chloride or copper(I) bromide and an additional oxidant like air. The base used in the original research paper is ammonia and the solvent is water or an alcohol.
As early as 1938, G. N. Lewis pointed out that the relative strength of an acid or base depended upon the base or acid against which it was measured. [1] No single rank order of acid or base strength can predict the energetics of the cross reaction. Consider the following pair of acid–base reactions:. 4F-C 6 H 4 OH + OEt 2 −ΔH = 5.94 kcal/mole
1-Hexanol (IUPAC name hexan-1-ol) is an organic alcohol with a six-carbon chain and a condensed structural formula of CH 3 (CH 2) 5 OH. This colorless liquid is slightly soluble in water, but miscible with diethyl ether and ethanol .
Three of these alcohols, 2-methyl-1-butanol, 2-pentanol, and 3-methyl-2-butanol (methyl isopropyl carbinol), contain stereocenters, and are therefore chiral and optically active. The most important amyl alcohol is isoamyl alcohol , the chief one generated by fermentation in the production of alcoholic beverages and a constituent of fusel oil .
Cyclohexane is a cycloalkane with the molecular formula C 6 H 12.Cyclohexane is non-polar.Cyclohexane is a colourless, flammable liquid with a distinctive detergent-like odor, reminiscent of cleaning products (in which it is sometimes used).
For example, the reaction of acetic anhydride with ethanol yields ethyl acetate: (CH 3 CO) 2 O + CH 3 CH 2 OH → CH 3 CO 2 CH 2 CH 3 + CH 3 COOH. Often a base such as pyridine is added to function as catalyst. In specialized applications, Lewis acidic scandium salts have also proven effective catalysts. [12]