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The Jackson Laboratory (often abbreviated as JAX) is an independent, ... (NIH) funds phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2).
The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ. NSG branded mice are among the most immunodeficient described to date. [1] NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells. [2]
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
White heterozygous mice can subsequently be crossed to produce mice that are homozygous for the knocked out gene. There are several variations to the procedure of producing knockout mice; the following is a typical example. The gene to be knocked out is isolated from a mouse gene library.
The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. [1] The mutation is recessive. Mutant mice are phenotypically indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice.
The Mouse Genetics Project (MGP) is a large-scale mutant mouse production and phenotyping programme aimed at identifying new model organisms of disease. [1] [2] [3] [4]Based at the Wellcome Trust Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium.
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to create knockout mice to study.
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]