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The elongation and membrane targeting stages of eukaryotic translation. The ribosome is green and yellow, the tRNAs are dark-blue, and the other proteins involved are light-blue. Elongation depends on eukaryotic elongation factors. At the end of the initiation step, the mRNA is positioned so that the next codon can be translated during the ...
Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...
13629 Ensembl ENSG00000167658 ENSMUSG00000034994 UniProt P13639 P58252 RefSeq (mRNA) NM_001961 NM_007907 RefSeq (protein) NP_001952 NP_031933 Location (UCSC) Chr 19: 3.98 – 3.99 Mb Chr 10: 81.01 – 81.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic ...
The eEF1A1 protein is an isoform of the eEF-1 complex alpha subunit, an elongation factor protein, a GTPase, and an actin bundling protein. [7] [8] [9] [14] As an elongation factor, it is known to mediate the recruitment of aminoacyl-tRNA to the A-site of the 80S ribosome during protein synthesis.
The ribosomal P-site plays a vital role in all phases of translation. Initiation involves recognition of the start codon (AUG) by initiator tRNA in the P-site, elongation involves passage of many elongator tRNAs through the P site, termination involves hydrolysis of the mature polypeptide from tRNA bound to the P-site, and ribosome recycling involves release of deacylated tRNA.
Due to the fact that translation elongation is an irreversible process, there are few known mechanisms of its regulation. However, it has been shown that translational efficiency is reduced via diminished tRNA pools, which are required for the elongation of polypeptides.
EF-G (elongation factor G, historically known as translocase) is a prokaryotic elongation factor involved in mRNA translation. As a GTPase , EF-G catalyzes the movement (translocation) of transfer RNA (tRNA) and messenger RNA (mRNA) through the ribosome .
EC 7.2.1 Translocation of inorganic cations linked to oxidoreductase reactions; EC 7.2.2 Translocation of inorganic cations linked to the hydrolysis of a nucleoside triphosphate; EC 7.2.4 Translocation of inorganic cations linked to decarboxylation; An important translocase contained in this group is Na+/K+ pump, also known as EC 7.2.2.13.