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The name comes from the idea that on a graph of concentration versus time, the line forms a U-shaped trough at the lowest region, before a new dose sends it higher again. The usual criterion is concentration in the blood serum , although in some instances local concentration within tissues is relevant.
Peak–trough fluctuation within one dosing interval at steady state. ... That is the 100 mg administered represents a blood plasma concentration of 80 mg that has ...
Peak-to-trough ratio in pharmacokinetics is the ratio of peak (C max) and trough (C min) levels of a drug over its dosing interval (τ) at steady state.. Peak-to-trough ratio (PTR), also known as peak-to-trough variation or peak-to-trough fluctuation, is a parameter in pharmacokinetics which is defined as the ratio of C max (peak) concentration and C min (trough) concentration over a dosing ...
In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.
C min is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from C trough, the concentration immediately prior to administration of the next dose. [1]
Tax cuts that mostly benefit the rich, rent-seeking oligarchs feeding from the public trough, blatant self-dealing in the Oval Office, and all of it possibly happening as “groceries” begin to ...
The initial concentration of any non-nutritive phytochemical in the blood plasma is zero unless a person has recently ingested a food or beverage. For example, as increasing amounts of green tea extract are consumed, a graded increase in plasma catechin can be measured, and the major compound is eliminated with a half-life of about 5 hours. [ 13 ]