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Differential diagnosis of troponin elevation includes acute infarction, severe pulmonary embolism causing acute right heart overload, heart failure, myocarditis. Troponins can also calculate infarct size but the peak must be measured in the 3rd day. After myocyte injury, troponin is released in 2–4 hours and persists for up to 7 days.
Troponin I is not entirely specific for myocardial damage secondary to infarction. Other causes of raised troponin I include chronic kidney failure, heart failure, subarachnoid haemorrhage and pulmonary embolus. [9] [10] In veterinary medicine, increased cTnI has been noted from myocardial damage after ionophore toxicity in cattle. [11]
Elevated troponin levels are prognostically important in many of the conditions in which they are used for diagnosis. [ 36 ] In a community-based cohort study indicating the importance of silent cardiac damage, troponin I has been shown to predict mortality and first coronary heart disease event in men free from cardiovascular disease at ...
The level of the troponin, as well as a change over time, are useful in measuring and diagnosing or excluding myocardial infarctions, and the diagnostic accuracy of troponin testing is improving over time. [72] One high-sensitivity cardiac troponin can rule out a heart attack as long as the ECG is normal. [83] [84]
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood.. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath, excessive fatigue, and bilateral leg swelling. [3]
Theoretically, a cardiac troponin activator could be useful for increasing cardiac contractility in the treatment of systolic heart failure, whereas a troponin inhibitor could be used to favor relaxation in the treatment of diastolic heart failure. Troponin modulators could also be used to reverse the impact of cardiomyopathy-causing mutations ...
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