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Solithromycin (trade name Solithera) is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia [1] and other infections. [ 2 ] Solithromycin exhibits excellent in vitro activity against a broad spectrum of Gram-positive respiratory tract pathogens , [ 3 ] [ 4 ] including macrolide-resistant ...
It is specifically used for otitis media, streptococcal pharyngitis, pneumonia, cellulitis, urinary tract infections, and animal bites. [5] It can be administered orally or intravenously. [2] Common side effects include diarrhea, vomiting, and allergic reactions. [5] It also increases the risk of yeast infections, headaches, and blood clotting ...
In the United States it is also indicated for the treatment of complicated urinary tract infections including pyelonephritis. [5] [7] [10] It is a potential effective alternative treatment for ceftriaxone-resistant gonorrhoea. [11] [12] It is given as an intravenous infusion or intramuscular injection. The drug is not approved for children ...
This includes strep throat, pneumonia, skin infections, H. pylori infection, and Lyme disease, among others. [3] Clarithromycin can be taken by mouth as a tablet or liquid or can be infused intravenously. [3] Common side effects include nausea, vomiting, headaches, and diarrhea. [3] Severe allergic reactions are rare. [3]
Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections, and empirical therapy in febrile neutropenia (e.g., after chemotherapy). The drug is administered intravenously every 6 or 8 hr, typically over 3–30 min. It may also be administered by continuous infusion over four hours.
Ampicillin/sulbactam is also used when the cause of an infection is not known (empiric therapy), such as intra-abdominal infections, skin infections, pneumonia, and gynecologic infections. It is active against a wide range of bacterial groups, including Staphylococcus aureus , Enterobacteriaceae , and anaerobic bacteria .
Its use as a prophylactic treatment is supported by one clinical trial involving children with acute lymphoblastic leukaemia. [59] Other than this and one other clinical trial into its efficacy as a treatment for pneumocystis pneumonia, [60] data on its use in both the treatment and prevention of pneumocystis pneumonia is significantly lacking.
It is used to treat complicated intra-abdominal infections, urinary tract infections, and pneumonia. [4] [5] It is only recommended when other options are not appropriate. [4] It is given by infusion into a vein. [4] Common side effect include nausea, fever, liver problems, headache, trouble sleeping, and pain at the site of infusion. [4]