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Tamoxifen treatment of postmenopausal women is associated with beneficial effects on serum lipid profiles. However, long-term data from clinical trials have failed to demonstrate a cardioprotective effect. [52] For some women, tamoxifen can cause a rapid increase in triglyceride concentration in the blood.
Adverse effects of tamoxifen include hot flashes and an increase in the risk of developing endometrial cancer compared to women of similar age. [ 6 ] [ 4 ] Toremifene , a chlorinated tamoxifen derivative developed to avoid hepatic carcinomas , was associated with fewer DNA adducts in the liver than tamoxifen in preclinical studies .
The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the most recent analyses suggesting that, when initiated within 10 years of menopause, HRT reduces all-cause mortality and risks of coronary disease, osteoporosis, and dementia; after 10 years the beneficial effects on mortality and coronary ...
Tamoxifen. Typically used to treat breast cancer, tamoxifen has been shown to prevent the progression of Peyronie’s disease in vitro when combined with the ED medication tadalafil.
One of the largest breast cancer prevention studies ever, [2] it included 22,000 women in 400 medical centers in the United States and Canada. [3] [4] [5] The study concluded that raloxifene caused fewer side-effects and less endometrial cancer than tamoxifen.
Most women over 60 have entered a new phase in life and health: post-menopause. According to Dr. Tara Scott, MD, gynecologist and Medical Advisor at Versalie, by the age of 60, most women are ...
2. Hormonal Changes. Premenopausal women who undergo ovary removal may lose hair due to the hormonal changes caused by the resulting menopause. During menopause, the body stops producing two ...
A report in September 2009, from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen and raloxifene used to treat breast cancer, significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects. [21]
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