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Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1]
The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.
The IC 50 (half-maximal inhibitory concentration) of cinnarizine for smooth muscle contraction inhibition is 60 mM [34] and it has been shown that this drug preferentially binds to its target calcium channels when they are in an open, as opposed to closed conformation. [35]
It is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. In other words, it can be defined as the concentration required to obtain a 50% effect. [3] Half maximal inhibitory concentration
[3] [5] As (S,S)-CE-158, its inhibitory potencies (IC 50 Tooltip half-maximal inhibitory concentration) at the monoamine transporters are 227 nM at the dopamine transporter (DAT), 11,970 nM at the norepinephrine transporter (NET) (53-fold lower), and inactive at the serotonin transporter (SERT).
Molindone is available in the form of 5, 10, 25, and 50 mg oral tablets. [1] Adverse effects ... (IC 50 Tooltip half-maximal inhibitory concentration = 84–140 ...
Nilutamide is available in the form of 50 and 150 mg oral tablets. [48] Side effects ... IC 50 Tooltip Half maximal inhibitory concentration (nM) RBA Tooltip Relative ...
Relugolix is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR), with a half-maximal inhibitory concentration (IC 50) of 0.12 nM. [1] [8] [9] A dosage of relugolix of 40 mg once per day has been found to suppress estradiol levels to postmenopausal levels (<20 pg/mL) within 24 hours in premenopausal women. [1]