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TCA overdose may occur by accident or purposefully in an attempt to cause death. [2] The toxic dose depends on the specific TCA. [ 2 ] Most are non-toxic at less than 5 mg/kg except for desipramine , nortriptyline , and trimipramine , which are generally non-toxic at less than 2.5 mg/kg.
Treatment of TCA overdose depends on severity of symptoms: Initially, gastric decontamination of the patient is achieved by administering, either orally or via a nasogastric tube , activated charcoal pre-mixed with water, which adsorbs the drug in the gastrointestinal tract (most useful if given within 2 hours of drug ingestion).
Traumatic cardiac arrest (TCA) is a condition in which the heart has ceased to beat due to blunt or penetrating trauma, such as a stab wound to the thoracic area. [1] It is a medical emergency which will always result in death without prompt advanced medical care.
Frank Wycheck, the NFL tight end best known for throwing the lateral that started the “Music City Miracle” and launched the Tennessee Titans’ run to the franchise’s lone Super Bowl ...
Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [4] [5] [2] Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. [2]
Its treatment centers are modeled after the Healing Place, also part of the network, in Louisville. “Clients work with peers in similar circumstances to motivate one another to adopt social skills and to learn core principles central to Alcoholics Anonymous and Narcotics Anonymous programs,” according to the facility’s promotional materials.
AGS can cause a range of symptoms: mild ones like a rash or hives, or more severe ones such as difficulty breathing, and even anaphylaxis, says infectious disease expert Amesh A. Adalja, M.D ...
Overdose of the medication can result in death. Imipramine appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors. Imipramine was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed.