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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity. [4] [5]
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Obesity isn’t just a matter of food and exercise — it may be in your genetic code, according to new research. “Obesity’s causes are very complex and in the majority of cases, the ...
By 2015, no state had a prevalence of obesity under 18%; almost all states exceeded 22%, and six states exceeded 26%. [10] According to the Centers for Disease Control and Prevention (CDC), in 2016 the number of obese people in the United States reached an all-time high of about 93 million, up 33% from 2008. [ 11 ]
Obesity has been associated with an inflammatory state, which is chronic and low-grade inflammation, known as meta-inflammation. [ 6 ] [ 7 ] Meta-inflammation is subclinical meaning that while there is an increase in circulating pro-inflammatory factors, no clinical signs of inflammation , heat, pain, and redness, are seen with meta ...
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Free fatty acid receptor 2 (FFAR2), also known as G-protein coupled receptor 43 (GPR43), is a rhodopsin-like G-protein coupled receptor (GPCR) encoded by the FFAR2 gene. [5] In humans, the FFAR2 gene is located on the long arm of chromosome 19 at position 13.12 (19q13.12).
The main problem with this idea is the timing at which the transition is presumed to have happened, and how this would then translate into the genetic predisposition to type 2 diabetes and obesity [citation needed]. For example, the decline in reproductive investment in human societies (the so-called r to K shift) has occurred far too recently ...