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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [ 2 ] [ 3 ] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
Using quantitative genetic analysis techniques, the researchers attempted to find either a causative or consequential relationship between the implicated genes and the obesity. They found that most of the interactions between the genes of interest and obesity were consequential—demonstrating that any alteration in gene activity is most likely ...
Experts have long known there is a genetic component to obesity, and a new study identified one particular gene that may be behind it. Researchers have found a ‘clear genetic trigger for obesity ...
In medicine, genetic susceptibility to a disease refers to a genetic predisposition to a health problem, [1] which may eventually be triggered by particular environmental or lifestyle factors, such as tobacco smoking or diet. Genetic testing is able to identify individuals who are genetically predisposed to certain diseases.
Some people’s genetics predispose them to obesity. But nature is not destiny. Here are five tips for losing weight.
Leptin is known to play a key role in appetite and thus weight regulation, and may be important in regulating the set point and regulating body weight towards the set point. Changing leptin levels – either associated with weight gain or loss, or induced via central or peripheral administration in animal models – directly alter feeding ...
Little or no school-related physical activity programs Too much sedentary time, especially involving video games and other screen-based activities Obesity risk factors for both children and adults ...