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2. Methotrexate - Wikipedia

   en.wikipedia.org/wiki/Methotrexate

   Methotrexate (green) complexed into the active site of DHFR (blue) Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.

3. Antiarthritics - Wikipedia

   en.wikipedia.org/wiki/Antiarthritics

   Methotrexate is commonly associated with dose-related toxic effects involving the bone marrow and gastrointestinal tract. [12] Folic acid may be given weekly to help diminish the frequency of side-effects. [12] Methotrexate is also associated with acute and chronic liver damage. Other adverse effects include: [12] Life-threatening Interstitial ...

4. Immunosuppressive drug - Wikipedia

   en.wikipedia.org/wiki/Immunosuppressive_drug

   Methotrexate is a folic acid analogue. It binds dihydrofolate reductase and prevents synthesis of tetrahydrofolate. It is used in the treatment of autoimmune diseases (for example rheumatoid arthritis or Behcet's Disease) and in transplantations.

5. What Is Methotrexate, Exactly, and How Does It Play Into ...

   www.aol.com/lifestyle/methotrexate-exactly-does...

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6. TNF inhibitor - Wikipedia

   en.wikipedia.org/wiki/TNF_inhibitor

   A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their ...

7. Rheumatoid arthritis - Wikipedia

   en.wikipedia.org/wiki/Rheumatoid_arthritis

   Rheumatoid arthritis is derived from the Greek word ῥεύμα-rheuma (nom.), ῥεύματος-rheumatos (gen.) ("flow, current"). The suffix -oid ("resembling") gives the translation as joint inflammation that resembles rheumatic fever. Rhuma which means watery discharge might refer to the fact that the joints are swollen or that the disease ...