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Schamberg's disease is a skin disorder that causes a discoloration of the lower extremities. [4] It usually occurs in the lower extremities and rarely elsewhere. [4] This condition is caused by leaky blood vessels near the surface of the skin. [7] The cause of the leaky capillaries is usually not known. [7]
Its differential diagnosis is broadly divided into possible blood diseases, autoimmune (rheumatologic), cardiovascular diseases, cancers, and endocrine disorders. It can usually (in 80% of cases) be diagnosed by biopsy. [3] It may be aggravated by exposure to cold, and occurs most often in the lower extremities. [4]
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
What it looks like: Lupus, a chronic autoimmune disease that causes inflammation throughout the body, often presents with a red, butterfly-shaped rash across the cheeks and nose. It is usually ...
Both are characterized by an immune system malfunction which may cause similar symptoms, such as rash, swelling, or fatigue, but the cardinal cause or mechanism of the diseases are different. A key difference is a malfunction of the innate immune system in autoinflammatory diseases, whereas in autoimmune diseases there is a malfunction of the ...
Dermatomyositis is a form of systemic connective tissue disorder, a class of diseases that often involves autoimmune dysfunction. [ 12 ] [ 16 ] It has also been classified as an idiopathic inflammatory myopathy , along with polymyositis, necrotizing autoimmune myositis, cancer-associated myositis , and sporadic inclusion body myositis .
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