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From 2015 to November 2022, the FDA issued dozens of warning letters to American manufacturers of CBD products for false advertising and illegal interstate marketing of CBD as an unapproved drug to treat diseases, such as cancer, osteoarthritis, symptoms of opioid withdrawal, Alzheimer's disease, and pet disorders. [58] Chemical analysis of CBD ...
CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [57] The terminal half-life is approximately 18–32 hours. [70]
CBD can interfere with the uptake of adenosine, which plays an important role in biochemical processes, such as energy transfer. It may play a role in promoting sleep and suppressing arousal. [28] CBD shares a precursor with THC and is the main cannabinoid in CBD-dominant Cannabis strains.
The researchers noted that there is “tentative support” for using CBD to treat social anxiety; there are also case studies that suggest cannabis may help with sleep and post-traumatic stress ...
Two new studies suggest once again the importance of getting a good night's sleep for good health over a ... Deep sleep can keep two big health problems at bay, new studies suggest. Show comments.
Winter brings less daylight and colder temperatures, which can disrupt sleep. Seasonal Affective Disorder (SAD) is more common in winter due to the lack of sunlight, causing sleep disturbances.
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Individuals with risk factors for psychotic disorders are often counseled against using synthetic cannabinoids. [81] Psychiatrists have suggested that the lack of an antipsychotic chemical, like CBD in natural cannabis , may make synthetic cannabinoids more likely to induce psychosis than natural cannabis.