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Amitriptyline is a highly lipophilic molecule having an octanol-water partition coefficient (pH 7.4) of 3.0, [132] while the log P of the free base was reported as 4.92. [133]
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).
The same group reviewed data for amitriptyline in the treatment of neuropathic pain and found limited useful randomized clinical trial data. They concluded that the long history of successful use in the community for the treatment of fibromyalgia and neuropathic pain justified its continued use. [ 67 ]
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Amitriptylinoxide (brand names Amioxid, Ambivalon, Equilibrin), or amitriptyline N-oxide, is a tricyclic antidepressant (TCA) which was introduced in Europe in the 1970s for the treatment of depression. [1] Amitriptylinoxide is both an analogue and metabolite of amitriptyline, and has similar effects as well as equivalent efficacy as an ...
Amitriptyline Nortriptyline (Amitriptyline's active metabolite) Perphenazine Notes SERT: 3.13: 16.5? It is this and its NET-inhibiting action is believed to give amitriptyline its antidepressant action. NET: 22.4: 4.37? See above. DAT: 5380: 3100? 5-HT 1A: 450: 294: 421: Binding for human brain receptors had to be substituted in amitriptyline ...
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Minitran 2-25: 2 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran 4-10: 4 mg Perphenazine and 10 mg Amitriptyline hydrochloride in each tablet. Minitran 4-25: 4 mg Perphenazine and 25 mg Amitriptyline hydrochloride in each tablet. Minitran is also a pharmaceutical drug for the treatment of Angina, manufactured by 3M