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Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
Ascorbic acid efflux by embryos of dicot plants is a well-established mechanism of iron reduction and a step obligatory for iron uptake. [a] All plants synthesize ascorbic acid. Ascorbic acid functions as a cofactor for enzymes involved in photosynthesis, synthesis of plant hormones, as an antioxidant and regenerator of other antioxidants. [96]
As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement. [2] Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).
An example of a mineral ascorbate drug is sodium ascorbate injections (the acid form, ascorbic acid, of vitamin c is too acidic for injections). Ascorbate salts may be better tolerated by the human body than the corresponding weakly acidic ascorbic acid. Ascorbates are highly reactive antioxidants used as food preservatives. [2]
“[This serum] combines 15% L-ascorbic acid, vitamin E, and ferulic acid to protect against free radicals, reduce oxidative damage by up to 41%, and improve fine lines, firmness, and skin tone ...
In in vitro studies, the primary mechanism of high dosage intravenous ascorbic acid can be related to ascorbic acid's pro-oxidant activity, whereby hydrogen peroxide is formed. [ 17 ] [ 18 ] [ 19 ] In the extracellular fluid of cells, ascorbic acid dissociates into an ascorbate radical upon the reduction of transition metal ions, such as ferric ...
It is the potassium salt of ascorbic acid and a mineral ascorbate. As a food additive, it has E number E303, INS number 303. Although it is not a permitted food additive in the UK, USA and the EU, [ 2 ] [ 3 ] it is approved for use in Australia and New Zealand. [ 4 ]
Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C. In addition to its use as a source of vitamin C, it is also used as an antioxidant food additive (E number E304). It is approved for use as a food additive in the EU, [1] the U.S., [2] Canada, [3] Australia, and New Zealand. [4]