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Unwanted weight loss of more than 5% within 6 months. [2] [19] For people with a BMI of less than 20 kg/m 2, weight loss of more than 2%. [2] [19] [27] For people with sarcopenia, weight loss of more than 2%. [2] [19] [27] New ways to score and stage cachexia are being explored, particularly in people with advanced cancer. [19]
Many people do not have any symptoms when they are first diagnosed. [8] [2] Those with symptoms (about 5-10% of patients with CLL) may experience the following: Fevers; Fatigue; Night sweats; Unexplained weight loss; Loss of appetite; Painless lymph node swelling; Enlargement of the spleen, and/or; A low red blood cell count . [10] [4] [2] [12]
Unexplained weight loss of at least 10% of the person's total body mass in six months or less [15] Low-grade fever. [15] Fatigue (lassitude) [15] Systemic symptoms such as fever, night sweats, and weight loss are known as B symptoms; thus, presence of these indicate that the person's stage is, for example, 2B instead of 2A. [15]
Intentional weight loss is the loss of total body mass as a result of efforts to improve fitness and health, or to change appearance through slimming. Weight loss is the main treatment for obesity, [1] [2] [3] and there is substantial evidence this can prevent progression from prediabetes to type 2 diabetes with a 7–10% weight loss and manage cardiometabolic health for diabetic people with a ...
Constitutional Symptoms. Unexplained weight loss: Weight loss that is unintended and not explained by diet, exercise or other illness may be a warning sign of many types of cancer; Unexplained pain: Pain that persists, has no clear cause, and does not respond to treatment may be a warning sign of many types of cancers.
Experts say that recent, unexplained weight loss is a "well-known phenomenon" associated with cancer. But other health conditions can cause weight loss as well.
Indeed, unintentional weight loss is an extremely significant predictor of mortality. [33] Terminally ill individuals often undergo weight loss before death, and classifying those individuals as lean greatly inflates the mortality rate in the normal and underweight categories of BMI, while lowering the risk in the higher BMI categories.
Cancer: CACH Childhood ataxia with central nervous system hypomyelination (see vanishing white matter disease) CAD Coronary artery disease: CADASIL: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy CAP Community acquired pneumonia: CAPA COVID-19–associated pulmonary aspergillosis CAPD