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Hyperkalemic periodic paralysis (HYPP, HyperKPP) is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood. It is characterized by muscle hyperexcitability or weakness which, exacerbated by potassium , heat or cold, can lead to uncontrolled shaking followed ...
Hyperkalemic periodic paralysis (HYPP, HyperKPP) is a genetic disorder that occurs in horses. It is also known as Impressive syndrome , after an index case in a horse named Impressive . It is an inherited autosomal dominant disorder that affects sodium channels in muscle cells and the ability to regulate potassium levels in the blood .
Hyperkalemic periodic paralysis is an autosomal dominant clinical condition where there is a mutation in gene located at 17q23 that regulates the production of protein SCN4A. SCN4A is an important component of sodium channels in skeletal muscles.
Periodic paralysis. Periodic paralysis is a group of rare genetic diseases that lead to weakness or paralysis [1] from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind. The underlying mechanism of these diseases are malfunctions in the ion channels in skeletal muscle ...
Breed: Breed-specific diseases, such as hyperkalemic periodic paralysis (HYPP), can be ruled out. Additionally, some breeds or types are more prone to certain types of lameness. Discipline: Certain lamenesses are associated with certain uses.
Impressive (horse) Impressive (April 15, 1969 – March 20, 1995) was an Appendix Quarter Horse, who earned his full AQHA registration in 1971. He was the 1974 World Champion Open Aged halter stallion, the first such World Champion in his breed, despite carrying only 48 halter points in total. He sired 2,251 foals, of which thirty went on to be ...
Additionally, defects in both GSY1 and the SCNA4 gene, responsible for hyperkalemic periodic paralysis (HYPP) in Quarter Horses and related breeds, has been found in 14% of Halter horses. [9] A combination of both of these genes can cause severe rhabdomyolysis should the horse become recumbent due to an HYPP attack. [1]
In Quarter Horses, hyperkalemic periodic paralysis (HYPP), an autosomal dominant disorder of potassium regulation, can be linked back to a single Quarter Horse sire called Impressive. Also known as Impressive syndrome, HYPP causes heavy muscling in carrier horses, which is a desirable trait in the show ring.