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Inflammatory conditions such as rheumatoid arthritis, gouty arthritis, and systemic lupus erythematosus can also contribute to hand deformities by affecting the joints. Degenerative arthritis, specifically osteoarthritis , functions to evoke impaired hand function due to the gradual deterioration of cartilage .
Rheumatoid arthritis (especially in patients with polycythaemia) [3] Eczema and psoriasis; Deep telangiectasias; Coxsackievirus A infection (Hand, foot and mouth disease) [4] Rocky Mountain spotted fever [4] Secondary syphilis [4] Kawasaki disease; Adverse drug reaction: palmoplantar erythrodysesthesia (acral erythema)
In humans and apes the AVAs are concentrated in the palms of the hands, the soles of the feet and the upper face. [1] It is more practical to apply a cooling medium to the palms of the hands, rather than to the soles of the feet or the face, so cooling the palms became the focus for researchers.
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People with severe involvement often show lumps on the back of their finger joints (called "Garrod's pads", "knuckle pads", or "dorsal Dupuytren nodules"), and lumps in the arch of the feet (plantar fibromatosis or Ledderhose disease). [2] In severe cases, the area where the palm meets the wrist may develop lumps.
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