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Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [ 1 ] They are named after their chemical structure , which contains three rings of atoms .
Tricyclic antidepressants, or TCAs, are an older class of antidepressants. They first came onto the market in the mid-20th century as treatments for depression and certain anxiety and pain disorders.
It’s worth noting that many of these common antidepressants don’t work instantly, and it may take some time for your body to adjust. ( Related : Wellbutrin vs Adderall: Differences and ...
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
The majority of the tricyclic antidepressants (TCAs) act primarily as serotonin–norepinephrine reuptake inhibitors (SNRIs) by blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET), respectively, which results in an elevation of the synaptic concentrations of these neurotransmitters, and therefore an enhancement of ...
Tricyclic antidepressants (TCAs) Atypical antidepressants While antidepressants are not addictive, other medications like benzodiazepines (used primarily to treat anxiety and panic disorders) have ...
Imipramine appears to work by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors. Imipramine was discovered in 1951 and was introduced for medical use in 1957. It was the first TCA to be marketed.
Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. [11] [12] Its effects may take up to four weeks but can also manifest as early as one to two weeks.