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2. Bottom-up proteomics - Wikipedia

   en.wikipedia.org/wiki/Bottom-up_proteomics

   There is limited protein sequence coverage by identified peptides, loss of labile PTMs, and ambiguity of the origin for redundant peptide sequences. [8] Recently the combination of bottom-up and top-down proteomics, so called middle-down proteomics, is receiving a lot of attention as this approach not only can be applied to the analysis of large protein fragments but also avoids redundant ...

3. List of mass spectrometry software - Wikipedia

   en.wikipedia.org/wiki/List_of_mass_spectrometry...

   MetaMorpheus is a proteomics search software developed at the University of Wisconsin-Madison with integrated calibration, post-translational modification discovery, bottom-up and top-down proteomics search, cross-linking mass spectrometry (XL-MS) search, proteogenomic search, and label-free quantification (LFQ) capabilities. [7] MSFragger Freeware

4. List of protein structure prediction software - Wikipedia

   en.wikipedia.org/wiki/List_of_protein_structure...

   Constituent amino-acids can be analyzed to predict secondary, tertiary and quaternary protein structure. This list of protein structure prediction software summarizes notable used software tools in protein structure prediction, including homology modeling, protein threading, ab initio methods, secondary structure prediction, and transmembrane helix and signal peptide prediction.

5. Galaxy (computational biology) - Wikipedia

   en.wikipedia.org/wiki/Galaxy_(computational_biology)

   Galaxy is open-source software implemented using the Python programming language. It is developed by the Galaxy team [23] at Penn State, Johns Hopkins University, Oregon Health & Science University, and the Galaxy Community. [24] Galaxy is extensible, as new command line tools can be integrated and shared within the Galaxy ToolShed. [25]

6. Mascot (software) - Wikipedia

   en.wikipedia.org/wiki/Mascot_(software)

   Mascot identifies proteins by interpreting mass spectrometry data. The prevailing experimental method for protein identification is a bottom-up approach, where a protein sample is typically digested with trypsin to form smaller peptides. While most proteins are too large, peptides usually fall within the limited mass range that a typical mass ...

7. List of open-source bioinformatics software - Wikipedia

   en.wikipedia.org/wiki/List_of_open-source...

   A workflow management system used for building and running scalable and reproducible bioinformatics pipelines, especially in cloud and high-performance computing environments. Linux, macOS, Windows: Apache License 2.0 Nextflow Team [6] PathVisio: Desktop software for drawing, analyzing, and visualizing biological pathways Linux, macOS, Windows ...

8. Skyline (software) - Wikipedia

   en.wikipedia.org/wiki/Skyline_(software)

   Skyline is an open source software for targeted proteomics [1] [2] and metabolomics [3] data analysis. It runs on Microsoft Windows and supports the raw data formats from multiple mass spectrometric vendors. It contains a graphical user interface to display chromatographic data for individual peptide or small molecule analytes.

9. Shotgun proteomics - Wikipedia

   en.wikipedia.org/wiki/Shotgun_proteomics

   Targeted proteomics using SRM and data-independent acquisition methods are often considered alternatives to shotgun proteomics in the field of bottom-up proteomics. While shotgun proteomics uses data-dependent selection of precursor ions to generate fragment ion scans, the aforementioned methods use a deterministic method for acquisition of ...