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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
SIRT1 protein promotes homologous recombination in human cells and is involved in recombinational repair of DNA breaks. [ 29 ] SIRT6 is a chromatin -associated protein and in mammalian cells is required for base excision repair of DNA damage . [ 30 ]
4837 18113 Ensembl ENSG00000166741 ENSMUSG00000032271 UniProt P40261 O55239 RefSeq (mRNA) NM_006169 NM_001311062 NM_010924 RefSeq (protein) NP_006160 NP_001358974 NP_001358975 NP_001358976 NP_001297991 NP_035054 Location (UCSC) Chr 11: 114.26 – 114.31 Mb Chr 9: 48.5 – 48.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nicotinamide N-methyltransferase (NNMT) is an enzyme that ...
10135 59027 Ensembl ENSG00000105835 ENSMUSG00000020572 UniProt P43490 Q99KQ4 RefSeq (mRNA) NM_005746 NM_182790 NM_021524 RefSeq (protein) NP_005737 NP_067499 Location (UCSC) Chr 7: 106.25 – 106.29 Mb Chr 12: 32.87 – 32.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse nicotinamide phosphoribosyltransferase Identifiers EC no. 2.4.2.12 CAS no. 9030-27-7 Databases IntEnz IntEnz view ...
Conversely, miR-132 has been implicated in promoting inflammation in adipocytes. The target for RNA silencing in this case is SirT1, a deacetylase enzyme. The p65 subunit of NF-κB is a SirT1 substrate; in the absence of SirT1 activity, NFκB is active, promoting inflammation and the production of the chemokines IL-8 and MCP-1.
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
22933 64383 Ensembl ENSG00000283100 ENSG00000068903 ENSMUSG00000015149 UniProt Q8IXJ6 Q8VDQ8 RefSeq (mRNA) NM_001193286 NM_012237 NM_030593 NM_001122765 NM_001122766 NM_022432 RefSeq (protein) NP_001180215 NP_036369 NP_085096 NP_001116237 NP_001116238 NP_071877 Location (UCSC) Chr 19: 38.88 – 38.9 Mb Chr 7: 28.47 – 28.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse NAD ...
n/a Ensembl ENSG00000284357 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 9.15 – 9.15 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 34a (miR-34a) is a microRNA that in humans is encoded by the MIR34A gene. Function microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene ...