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Cefoperazone contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain.As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram (Antabuse effect), due to inhibition of aldehyde dehydrogenase.
Cefoperazone/sulbactam is a combination drug used as an antibiotic. It is effective for the treatment of urinary tract infections . [ 2 ] It contains cefoperazone , a β-lactam antibiotic , and sulbactam , a β-lactamase inhibitor , which helps prevent bacteria from breaking down cefoperazone.
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. ...
The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States. [4] The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023. [5]
Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic.The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally.
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Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death.
There are several relevent pubchem entries, each of which describe a unique species that is generally called "cefoperazone" or "cefoperazon". 44185 and 44187 are chiral isomers. 44185; 44186; 44187; 16052030 - sodium salt; 6420003-dihydrate; Fuzzform 22:52, 28 May 2007 (UTC)