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Drug Adverse effects Cinchona bark Cinchona pubescens: Warfarin Possible additive effect [3] Chamomile: Blood thinners [23] Devil's Claw: grapple plant, wood spider Harpagophytum: Warfarin Additive effect [3] Ephedra Ephedra: Caffeine, decongestants, stimulants [15] Increases sympathomimetic effect of ephedra [3] Feverfew: featherfew Tanacetum ...
The efficacy of dantrolene in humans was later confirmed in a large, multicenter study published in 1982, [21] and confirmed epidemiologically in 1993. [22] Before dantrolene, the only available treatment for malignant hyperthermia was procaine, which was associated with a 60% mortality rate in animal models. [20]
pentoxyfylline – xanthine derivative used in as an antiinflammatory drug and in the prevention of endotoxemia; pergolide – dopamine receptor agonist used for the treatment of pituitary pars intermedia dysfunction in horses; phenobarbital – anti-convulsant used for seizures; phenylbutazone – nonsteroidal anti-inflammatory drug (NSAID)
On January 5, 2007, the U.S. Food and Drug Administration (FDA) approved Slentrol, the first time the FDA has approved a drug for obese dogs. [3] [4]However, concerns have since been raised, since 2010, about adverse effects [5] that might more strongly affect particular breeds.
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
After the widespread introduction of treatment with dantrolene, the mortality of malignant hyperthermia fell from 80% in the 1960s to less than 5%. [5] Dantrolene remains the only drug known to be effective in the treatment of MH. [30] The recommended dose of dantrolene is 2.5 mg/kg, repeated as necessary. [5]
The US Food and Drug Administration FDA reports [10] that some drugs in this class (isoxazolines), including afoxolaner, can have adverse neurologic effects on some dogs, such as muscle tremors, ataxia, and convulsions. Extralabel use of afoxolaner in a pet pig has been described without any adverse effects. [11]
Nitrofurazone is indicated for topical use in dogs, cats, and horses, for the treatment or prophylactic treatment of superficial bacterial infections, burns, and cutaneous ulcers. [9] Preparations for treating infections, such as fin rot , in ornamental fish are also still commercially available.
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