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Methylphosphonyl dichloride (DC) or dichloro is an organophosphorus compound. It has commercial application in oligonucleotide synthesis, [1] but is most notable as being a precursor to several chemical weapons agents. It is a white crystalline solid that melts slightly above room temperature. [2]
Methylphosphonic acid is an organophosphorus compound with the chemical formula CH 3 P(O)(OH) 2. The phosphorus center is tetrahedral and is bonded to a methyl group, two OH groups and an oxygen. Methylphosphonic acid is a white, non-volatile solid that is poorly soluble in organic solvent but soluble in water and common alcohols.
Methyldichlorophosphine is produced by alkylation of phosphorus trichloride with methyl iodide followed by reduction of the resulting phosphonium salt with iron powder: [2] [3] CH 3 I + PCl 3 + AlCl 3 → [CH 3 PCl 3 ] + AlCl 3 I −
NH 3 + 3 H 3 PO 3 + 3 CH 2 O → N(CH 2 PO 3 H 2) 3 + 3 H 2 O. Phosphonic acid also can be alkylated with acrylic acid derivatives to afford carboxyl functionalized phosphonic acids. This reaction is a variant of the Michael addition: CH 2 =CHCO 2 R + 3 H 3 PO 3 → (HO) 2 P(O)CH 2 CH 2 CO 2 R
[2] Dimethyl methylphosphonate is a schedule 2 chemical as it may be used in the production of chemical weapons. It will react with thionyl chloride to produce methylphosphonic acid dichloride, which is used in the production of sarin and soman nerve agents. Various amines can be used to catalyse this process. [3]
Synthesis of [Cp*RhCl 2] 2 using hexamethyl Dewar benzene. This complex was first prepared from hexamethyl Dewar benzene and RhCl 3 (H 2 O) 3 . [ 3 ] [ 4 ] [ 5 ] The hydrohalic acid necessary for the ring-contraction rearrangement is generated in situ in methanolic solutions of the rhodium salt, and the second step has been carried out ...
Methylphosphonyl difluoride (DF), also known as EA-1251 [2] or difluoro, [3] is a chemical weapon precursor. Its chemical formula is CH 3 POF 2.It is a Schedule 1 substance under the Chemical Weapons Convention.
Its conjugate bases, such as [N(CH 2 PO 3 H) 3] 3-, have chelating properties. ATMP can be synthesized from the Mannich-type reaction of ammonia, formaldehyde, and phosphorous acid , in a manner similar to the Kabachnik–Fields reaction .