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Blastic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which more than 30% of the cells in the blood or bone marrow are blast cells (immature blood cells). When tiredness , fever , and an enlarged spleen occur during the blastic phase, it is called blast crisis .
Blast crisis is the terminal phase of CML and clinically behaves like an acute leukemia. Drug treatment will usually stop this progression if early. One of the drivers of the progression from chronic phase through acceleration and blast crisis is the acquisition of new chromosomal abnormalities (in addition to the Philadelphia chromosome). [7]
Chronic myelogenous leukemia (CML), accelerated phase or blast crisis; Lymphomas. Hodgkin's disease; Non-Hodgkin's lymphoma; Myelomas. Multiple myeloma (Kahler's disease) Solid tumor cancers Neuroblastoma; Desmoplastic small round cell tumor; Ewing's sarcoma; Choriocarcinoma; Hematologic disease. Phagocyte disorders. Myelodysplasia; Anemias
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Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing. [1] Symptoms
However, while Numb is overexpressed during the chronic phase and decreases in the blast one, Musashi starts to be overexpressed in the last fatal phase of CML. [14] The high expression of MSI2 interrupts the cellular differentiation and allows the expansion of immature leukemic cells causing the progress to the deadly phase. [14]
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This system stratifies cases into 2 groups; a lower-risk group (sub divided into low and intermediate-1) and a higher risk (subdivided into intermediate-2 and high). It uses the blast percentage, number of cytopenias and bone marrow cytogenetics data to place cases of CMML into these groups.
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