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Each component of the collecting duct system contains two cell types, intercalated cells and a segment-specific cell type: For the connecting tubules, this specific cell type is the connecting tubule cell; For the collecting ducts, it is the principal cell.
11827 Ensembl ENSG00000167580 ENSMUSG00000023013 UniProt P41181 P56402 RefSeq (mRNA) NM_000486 NM_009699 RefSeq (protein) NP_000477 NP_033829 Location (UCSC) Chr 12: 49.95 – 49.96 Mb Chr 15: 99.48 – 99.48 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular ...
Acting on the nuclear mineralocorticoid receptors (MR) within the principal cells of the distal tubule and the collecting duct of the kidney nephron, it upregulates and activates the basolateral Na + /K + pumps, which pumps three sodium ions out of the cell, into the interstitial fluid and two potassium ions into the cell from the interstitial ...
An extensive listing of human cell types was published by Vickaryous and Hall in 2006, collecting 411 different types of human cells (with 145 types of neuron among those). [ 11 ] The Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells ) and sub-types in ...
It is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. [6] Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including the skin, respiratory tract, and kidneys as well as various types of cancers. [7]
The principal cells are the sodium ... then a regulation of the absorption of still more than 1000 mmoles/day entering the collecting duct system has a substantial ...
Aldosterone normally adds sodium channels in the principal cells of the collecting duct and late distal tubule of the nephron. Spironolactone prevents aldosterone from entering the principal cells, preventing sodium reabsorption. Similar agents are eplerenone and potassium canreonate. [citation needed]
Collecting duct system; S1 S2 S3 descending limb: thin ascending limb: thick ascending limb: connecting tubule: initial collecting tubule cortical collecting ducts medullary collecting ducts reabsorption (%) reabsorption (mmoles/day) Concentration (mM) 115 [1] 135 [1] electrical driving force (mV) −3 [2] +3 [2] +15 [2] −5 to +5 [2] −40 [2 ...