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Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Thalidomide is racemic; while S-thalidomide is the bioactive form of the molecule, the individual enantiomers can racemize to each other due to the acidic hydrogen at the chiral centre, which is the carbon of the glutarimide ring bonded to the phthalimide substituent. The racemization process can occur in vivo.
Thalidomide: 1961 Germany Withdrawn because of risk of teratogenicity; [62] returned to market for use in leprosy and multiple myeloma under FDA orphan drug rules Thenalidine: 1963 Canada, UK, US Neutropenia [3] [63] Thiobutabarbitone: 1993 Germany Kidney injury. [3] Thioridazine (Melleril) 2005 Germany, UK
Jose Daniel Ferrer, the leader of one of the largest banned anti-government groups in Cuba, was released two days after a surprise flurry of diplomatic activity involving the communist-run island ...
The historic protests in Cuba stem from frustration over acute shortages and the communist governemnt's failure to improve the economy amid the pandemic.
Wonder Drug: The Secret History of Thalidomide in America and Its Hidden Victims is a nonfiction book authored by Jennifer Vanderbes and published by Random House in 2023. It tells the story of how Frances Oldham Kelsey of the Food and Drug Administration (FDA) found flaws in thalidomide research.
According to many, the U.S. embargo against Cuba was also about deposing former President and former Prime Minister of Cuba Fidel Castro - a Marxist leader who violently overthrew the previous ...
Other contraceptives and methods of birth control are still very commonly used in Cuba, in addition to abortion, as means of fertility regulation. [3] While abortion remains a highly popular method for fertility regulation in Cuba, the IUD and oral contraceptives are the most popular preventative measures against pregnancy for Cuban women. [2]