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Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis , blastomycosis , coccidioidomycosis , cryptococcosis , histoplasmosis , dermatophytosis , and tinea versicolor . [ 5 ]
A one-time dose of fluconazole by mouth is 90% effective in treating a vaginal yeast infection. [70] For severe nonrecurring cases, several doses of fluconazole is recommended. [20] Local treatment may include vaginal suppositories or medicated douches. Other types of yeast infections require different dosing.
Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). In particular, it is active against Aspergillus, which fluconazole is not. The mechanism of action of itraconazole is the same as the other azole antifungals: it inhibits the fungal-mediated synthesis of ergosterol.
It is the first time the fungus has been identified in the U.S. Last year, doctors in France reported 13 such cases . Twelve of those patients were men who have sex with men.
The general mechanism of action for topical antifungal drugs is the disruption of the cell membrane. The unique components found in fungal cell membranes are usually the drug targets of antifungal drugs, in particular ergosterol. It is a sterol, which is important in maintaining proper membrane fluidity and normal functions of the cell membrane.
The mode of action is obscure. [31] Potassium permanganate - for use only on thicker, more insensitive skin such as the soles of the feet. Selenium disulfide; Sodium thiosulfate; Sulfur; Tolnaftate – a thiocarbamate antifungal, which inhibits fungal squalene epoxidase (similar mechanism to allylamines like terbinafine) [medical citation needed]
The flu can last for 5-7 days for healthy teens and adults, and two weeks or more for vulnerable populations. Talk to your doctor if you think you have the flu.
The duration of action of a drug is the length of time that particular drug is effective. [5] Duration of action is a function of several parameters including plasma half-life, the time to equilibrate between plasma and target compartments, and the off rate of the drug from its biological target. [6]
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