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The Lewis antigen system is a human blood group system. It is based upon two genes on chromosome 19 : FUT3 , or Lewis gene; and FUT2 , or Secretor gene. Both genes are expressed in glandular epithelia.
Carbohydrate antigen 19-9 (CA19-9), also known as sialyl-Lewis A, is a tetrasaccharide which is usually attached to O-glycans on the surface of cells. It is known to play a role in cell-to-cell recognition processes. It is also a tumor marker used primarily in the management of pancreatic cancer. [1]
The i antigen is made of linear repeats, while the structure of the I antigen is branched. [3] Unlike most other blood groups, the two antigens are not encoded by different alleles; rather, I-branching enzyme converts i antigen to I antigen by adding branches. [5] [6] The gene encoding I-branching enzyme is located on chromosome 6. [6]
The term human blood group systems is defined by the International Society of Blood Transfusion (ISBT) as systems in the human species where cell-surface antigens—in particular, those on blood cells—are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", [1] and include the common ABO and Rh ...
Printable version; In other projects ... Colton antigen system; ... Lan blood group system; Lewis antigen system; LU domain;
This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides during the final step of Lewis antigen biosynthesis. It encodes an enzyme with both alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
The LW blood system was first described by Landsteiner and Wiener in 1940. [1] It was often confused with the Rh system, not becoming a separate antigen system until 1982. The LW and RhD antigens are genetically independent though they are phenotypically related and the LW antigen is expressed more strongly on RhD positive cells than on RhD negative cells.
Lewis structure, a diagram of a molecule that shows the bonding between the atoms; Lewis acids and bases; Lewis antigen system, a human blood group system; Lewis number, a dimensionless number in fluid dynamics and transport phenomena; Lewis rat, an inbred strain of laboratory rat