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Cathepsin E is an enzyme (EC 3.4.23.34) that in humans is encoded by the CTSE gene. [5] [6] [7] The enzyme is also known as slow-moving proteinase, erythrocyte membrane aspartic proteinase, SMP, EMAP, non-pepsin proteinase, cathepsin D-like acid proteinase, cathepsin E-like acid proteinase, cathepsin D-type proteinase) is an enzyme.
162,041 structures in the PDB have a structure factor file. 11,242 structures have an NMR restraint file. 5,774 structures in the PDB have a chemical shifts file. 13,388 structures in the PDB have a 3DEM map file deposited in EM Data Bank. Most structures are determined by X-ray diffraction, but about 7% of structures are determined by protein ...
Cathepsin D (an aspartyl protease) appears to cleave a variety of substrates such as fibronectin and laminin. Unlike some of the other cathepsins, cathepsin D has some protease activity at neutral pH. [12] High levels of this enzyme in tumor cells seems to be associated with greater invasiveness.
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13033 Ensembl ENSG00000117984 ENSMUSG00000007891 UniProt P07339 P18242 RefSeq (mRNA) NM_001909 NM_009983 RefSeq (protein) NP_001900 NP_034113 Location (UCSC) Chr 11: 1.75 – 1.76 Mb Chr 7: 141.93 – 141.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a ...
20788 Ensembl ENSG00000198911 ENSMUSG00000022463 UniProt Q12772 Q3U1N2 RefSeq (mRNA) NM_004599 NM_033218 RefSeq (protein) NP_004590 NP_150087 Location (UCSC) Chr 22: 41.83 – 41.91 Mb Chr 15: 82.03 – 82.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ...
76429 Ensembl ENSG00000107902 ENSMUSG00000030946 UniProt Q9H008 Q9D7I5 RefSeq (mRNA) NM_001167880 NM_022126 NM_001318331 NM_001318332 NM_029609 RefSeq (protein) NP_001161352 NP_001305260 NP_001305261 NP_071409 NP_083885 Location (UCSC) Chr 10: 124.46 – 124.62 Mb Chr 7: 132.21 – 132.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholysine phosphohistidine inorganic ...
Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis. [5] In humans, cathepsin B is encoded by the CTSB gene. [6] [7] Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions. [8] [9 ...