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Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines, the oral route is unsuitable for certain substances, such as salvinorin A .
Sublingual administration is when medication is placed under the tongue to be absorbed by the body. The word "sublingual" means "under the tongue." Buccal administration involves placement of the drug between the gums and the cheek. These medications can come in the form of tablets, films, or sprays.
The sublingual gland (glandula sublingualis) is a seromucous polystomatic exocrine gland.Located underneath the oral diaphragm (diaphragma oris), the sublingual gland is the smallest and most diffuse of the three major salivary glands of the oral cavity, with the other two being the submandibular and parotid.
These drain into ducts situated between the lobes of the gland (called interlobular ducts or secretory ducts). These are found on most major and minor glands (exception may be the sublingual gland). [17] All of the human salivary glands terminate in the mouth, where the saliva proceeds to aid in digestion.
The floor is formed by the mylohyoid muscles and is occupied mainly by the anterior two-thirds of the tongue. A mucous membrane – the oral mucosa, lines the sides and under surface of the tongue to the gums, and lines the inner aspect of the jaw . It receives secretions from the submandibular and sublingual salivary glands.
The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the absorption of vitamin B12. Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands – transcobalamin I also called haptocorrin, which protects the acid ...
It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is mostly of endodermal origin and is continuous with the skin at body openings such as the eyes , eyelids , ears , inside the nose , inside the mouth , lips , the genital areas , the urethral opening and the anus .
Granular cell tumour: These are also tumours arising from neural cells, though it was incorrectly thought to arise from muscle cells and therefore previously called granular cell myoblastoma. It also is slow growing large painless and occurs mostly in the tongue.