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Persistent Müllerian duct syndrome (PMDS), also known as persistent oviduct syndrome, is a congenital disorder related to male sexual development. PMDS usually affects phenotypically normal male individuals with the karyotype (46, XY) and is a form of pseudohermaphroditism. [10] [11]
When this happens the individuals develop structures that are derived from the paramesonephric duct, and also structures that are derived from the mesonephric duct. A male that has persistent Müllerian duct syndrome may have an upper vagina, uterus, and uterine tubes as well as ductus deferens along with male external genitalia. The female ...
The Müllerian ducts only develop in the absence of anti-Müllerian hormone, where the Wolffian ducts regress. [ citation needed ] Development of the female reproductive tract begins at approximately week 8 of embryonic development, and development of the Müllerian duct system is typically complete by the end of the first trimester .
m, m. Right and left Müllerian ducts uniting together and running with the Wolffian ducts in gc, the genital cord: m. Müllerian duct, the upper part of which remains as the hydatid of Morgagni; the lower part, represented by a dotted line descending to the prostatic utricle, constitutes the occasionally existing cornu and tube of the uterus ...
The ducts pass backward lateral to the mesonephric ducts, but toward the posterior end of the embryo they cross to the medial side of these ducts, and thus come to lie side by side between and behind the latter—the four ducts forming what is termed the common genital cord [citation needed], to distinguish it from the genital cords of the ...
In a male embryo, the testicular cords will induce the development of the Wolffian duct into the vas deferens, epididymis and the seminal vesicle and cause the repression and regression of the Mullerian duct. [4] The other male sex organs (ex. the prostate) as well as external genitalia are also formed under the influence of testosterone. [4]
268 11705 Ensembl ENSG00000104899 ENSMUSG00000035262 UniProt P03971 P27106 Q5EC55 RefSeq (mRNA) NM_000479 NM_007445 RefSeq (protein) NP_000470 NP_031471 Location (UCSC) Chr 19: 2.25 – 2.25 Mb Chr 10: 80.64 – 80.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting hormone (MIH), is a glycoprotein hormone structurally ...
The developing tubules within the testes secretes a polypeptide Müllerian inhibition factor (MIF). MIF causes the regression of the paramesonephritic ducts 60 days after fertilization. Testosterone secretion by the interstitial cells of the testes then causes the growth and development of the mesonephric ducts into male secondary sex organs. [7]