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  2. Nitric oxide synthase - Wikipedia

    en.wikipedia.org/wiki/Nitric_oxide_synthase

    The first nitric oxide synthase to be identified was found in neuronal tissue (NOS1 or nNOS); the endothelial NOS (eNOS or NOS3) was the third to be identified. They were originally classified as "constitutively expressed" and "Ca 2+ sensitive" but it is now known that they are present in many different cell types and that expression is ...

  3. Endothelial NOS - Wikipedia

    en.wikipedia.org/wiki/Endothelial_NOS

    Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an enzyme that in humans is encoded by the NOS3 gene located in the 7q35-7q36 region of chromosome 7. [5]

  4. Biological functions of nitric oxide - Wikipedia

    en.wikipedia.org/wiki/Biological_functions_of...

    Biological functions of nitric oxide are roles that nitric oxide plays within biology. Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of N O. In mammals including humans, nitric oxide is a signaling molecule involved in several physiological and pathological processes. [1]

  5. Endothelium-derived relaxing factor - Wikipedia

    en.wikipedia.org/wiki/Endothelium-derived...

    EDRF is produced from L-arginine by an enzyme (endothelial nitric oxide synthase) that is dependent on calcium-calmodulin and NADPH - this occurs in the cardiac endothelium. [citation needed] EDRF then diffuses to the smooth muscle in vascular tissue (vessels may be large or small), here it enacts endogenous vasodilation. Moreover, it serves ...

  6. Argininosuccinate synthase - Wikipedia

    en.wikipedia.org/wiki/Argininosuccinate_synthase

    The enzyme endothelial nitric oxide synthase produces nitric oxide from arginine in endothelial cells. [9] Argininosuccinate synthetase and argininosuccinate lyase recycle citrulline, a byproduct of nitric oxide production, into arginine. Since nitric oxide is an important signaling molecule, this role of ASS is important to vascular physiology.

  7. Endothelium - Wikipedia

    en.wikipedia.org/wiki/Endothelium

    The most prevailing mechanism of endothelial dysfunction is an increase in reactive oxygen species, which can impair nitric oxide production and activity via several mechanisms. [27] The signalling protein ERK5 is essential for maintaining normal endothelial cell function. [28]

  8. Endothelial dysfunction - Wikipedia

    en.wikipedia.org/wiki/Endothelial_dysfunction

    The main cause of endothelial dysfunction is impaired bioavailability of nitric oxide. [ 1 ] In addition to acting as a semipermeable membrane , the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin , and by controlling local ...

  9. Endothelial activation - Wikipedia

    en.wikipedia.org/wiki/Endothelial_activation

    Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. [1] It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis , among others. [ 2 ]

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