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S.aureus produces two forms of coagulase (i.e., bound coagulase and free coagulase). Bound coagulase, otherwise known as "clumping factor", can be detected by carrying out a slide coagulase test, and free coagulase can be detected using a tube coagulase test.
In addition, pathogenic bacteria may secrete agents that alter the coagulation system, e.g. coagulase and streptokinase. [39] Immunohemostasis is the integration of immune activation into adaptive clot formation. Immunothrombosis is the pathological result of crosstalk between immunity, inflammation, and coagulation.
[citation needed] S. lugdunensis may produce a bound coagulase (that is, the enzyme is bound to the cells), a property it shares with S. aureus, but unlike S. aureus, it does not produce a free coagulase. In the laboratory, it can give a positive slide-coagulase test but a negative tube-coagulase test.
Staphylococcus aureus produces various enzymes such as coagulase (bound and free coagulases) which facilitates the conversion of fibrinogen to fibrin to cause clots which is important in skin infections. [57] Hyaluronidase (also known as spreading factor) breaks down hyaluronic acid and helps in spreading it.
Staphylococcus schleiferi is a Gram-positive, cocci-shaped bacterium of the family Staphylococcaceae. [1] It is facultatively anaerobic, coagulase-variable, and can be readily cultured on blood agar where the bacterium tends to form opaque, non-pigmented colonies and beta (β) hemolysis. [2]
Clumping factor A, or ClfA, is a virulence factor from Staphylococcus aureus (S. aureus) that binds to fibrinogen.. ClfA also has been shown to bind to complement regulator I protein.
[12] [13] It is sensitive to novobiocin, providing an important test to distinguish it from Staphylococcus saprophyticus, which is coagulase-negative, as well, but novobiocin-resistant. [4] Similar to those of S. aureus, the cell walls of S. epidermidis have a transferrin-binding protein that helps the organism obtain iron from transferrin. The ...
Tests in platelet poor plasma or in platelet free plasma (convenient for transportation; can be frozen; possibility to use optical observation methods; but the thrombocyte component of the hemostasis is not taken into account), Tests in platelet rich plasma (close to real conditions in the body, but restrictions as to the terms of work),