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Lugol's iodine is a liquid made up of two parts potassium iodide for every one part elemental iodine in water. [8] Lugol's iodine was first made in 1829 by the French physician Jean Lugol. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] [10] Lugol's iodine is available as a generic medication and over the ...
Retrieved from "https://en.wikipedia.org/w/index.php?title=Lugol’s_solution&oldid=759510077"This page was last edited on 11 January 2017, at 16:20
Lugol's solution or Lugol's iodine (IKI) is a brown solution that turns black in the presence of starches and can be used as a cell stain, making the cell nuclei more visible. Used with common vinegar (acetic acid), Lugol's solution is used to identify pre-cancerous and cancerous changes in cervical and vaginal tissues during "Pap smear" follow ...
In the latter case, an overlay of blue and red can be observed in Lugol's solution without KOH pretreatment: a color change from blue to dirty reddish-brown occurs when the iodine reagent slowly diffuses into the water preparation, because the euamyloid reaction appears at lower iodine concentrations than the hemiamyloid reaction.
Unlike the Wolff–Chaikoff effect, the Plummer effect does not prevent the thyroid from taking up radioactive iodine, e.g. in the case of nuclear emergencies.Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [9]
Lugol's iodine solution is always added after addition of crystal violet to form a stable complex with crystal violet that strengthen the bonds of the stain with the cell wall. [ 4 ] Gram staining is almost always the first step in the identification of a bacterial group.
One approach involves the introduction of Lugol's iodine solution, which effectively immobilizes the cytoplasmic streaming. [ citation needed ] Alternatively, the compound Cytochalasin D , dissolved in dimethyl sulfoxide , can be employed to achieve a similar effect by disrupting the actin microfilaments responsible for facilitating cytoplasmic ...
Schiller's iodine solution is applied to the cervix under direct vision. Normal cervical mucosa contains glycogen and stains brown, whereas abnormal areas, such as early cervical cancer, do not take up the stain. The abnormal areas can then be biopsied and examined histologically. The composition of Schiller's iodine is the same as Lugol's ...