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In addition to hot flashes triggered by menopause-associated hormone changes, medical conditions such as urinary tract infections, migraines, neurological disorders like multiple sclerosis and ...
Estrogen deficiency is also associated with an increased risk of cardiovascular disease, [1] and has been linked to diseases like urinary tract infections [2] and osteoporosis. In women, low levels of estrogen may cause symptoms such as hot flashes, sleeping disturbances, decreased bone health, [3] and changes in the genitourinary system.
Research on hot flashes is mostly focused on treatment options. The exact cause and pathogenesis, or causes, of vasomotor symptoms (VMS)—the clinical name for hot flashes—has not yet been fully studied. [11] [12] Hot flashes are associated with declining levels of estrogen (estrogen withdrawal) and other hormonal changes. [13]
There was a 5.2% increase in the incidence of hot flushes, 1.6% increase in urinary tract infections, and 0.5% increase in the incidence of headache with ospemifene over placebo. [14] One of the phase 3 trials was a randomized, double-blind placebo-controlled trial in 826 post-menopausal women. [15]
More than 80% of women experience hot flashes during menopause, the FDA noted, as the body gradually produces lower levels of reproductive hormones between the ages of 45 and 55.
Hot flashes—officially called vasomotor menopausal symptoms—come on with little warning. These scorching power surges can keep you up at night (the dreaded night sweats), leaving you and your ...
Monotherapy with NSAAs including bicalutamide, flutamide, nilutamide, and enzalutamide shows a significantly lower risk of certain side effects, including hot flashes, depression, fatigue, loss of libido, and decreased sexual activity, relative to treatment with GnRH analogues, CAB (NSAA and GnRH analogue combination), CPA, or surgical ...
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