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Endogenous cardiac stem cells were first discovered in 2003 by Bernardo Nadal-Ginard, Piero Anversa and colleagues [2] [3] in the adult rat heart and since then have been identified and isolated from mouse, dog, porcine and human hearts. [4] [5] The adult heart was previously thought to be a post mitotic organ without any regenerative capability.
Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical ...
This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. In the unphosphorylated state, phospholamban is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca 2+ -ATPase ( SERCA2 ) [ 7 ] which transports calcium from cytosol into the sarcoplasmic reticulum .
Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases [4] and conditions such as diabetes and heart disease. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create ...
Vitamin C is an essential nutrient involved in the repair of ... and calcium ascorbate. [40] Vitamin C molecules can ... treatment will suppress cancer stem cells, ...
These calcium ions bind to and open more calcium channels (called ryanodine receptors) located on the sarcoplasmic reticulum within the cell, allowing the flow of calcium out of the SR. These calcium ions are responsible for the contraction of the heart. Calcium also activates chloride channels called I to2, which allow Cl − to enter the cell ...
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Adult stem cells, also called somatic (from Greek σωματικóς, "of the body") stem cells, are stem cells which maintain and repair the tissue in which they are found. [44] There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, usually from pelvic bones via ...
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