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  2. Endogenous cardiac stem cell - Wikipedia

    en.wikipedia.org/wiki/Endogenous_cardiac_stem_cell

    Endogenous cardiac stem cells were first discovered in 2003 by Bernardo Nadal-Ginard, Piero Anversa and colleagues [2] [3] in the adult rat heart and since then have been identified and isolated from mouse, dog, porcine and human hearts. [4] [5] The adult heart was previously thought to be a post mitotic organ without any regenerative capability.

  3. Cellular cardiomyoplasty - Wikipedia

    en.wikipedia.org/wiki/Cellular_cardiomyoplasty

    Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. The ability of transplanted progenitor cells to improve function within the failing heart has been shown in experimental animal models and in some human clinical ...

  4. Phospholamban - Wikipedia

    en.wikipedia.org/wiki/Phospholamban

    This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. In the unphosphorylated state, phospholamban is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca 2+ -ATPase ( SERCA2 ) [ 7 ] which transports calcium from cytosol into the sarcoplasmic reticulum .

  5. Stem-cell therapy - Wikipedia

    en.wikipedia.org/wiki/Stem-cell_therapy

    Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases [4] and conditions such as diabetes and heart disease. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create ...

  6. Vitamin C - Wikipedia

    en.wikipedia.org/wiki/Vitamin_C

    Vitamin C is an essential nutrient involved in the repair of ... and calcium ascorbate. [40] Vitamin C molecules can ... treatment will suppress cancer stem cells, ...

  7. Cardiac action potential - Wikipedia

    en.wikipedia.org/wiki/Cardiac_action_potential

    These calcium ions bind to and open more calcium channels (called ryanodine receptors) located on the sarcoplasmic reticulum within the cell, allowing the flow of calcium out of the SR. These calcium ions are responsible for the contraction of the heart. Calcium also activates chloride channels called I to2, which allow Cl − to enter the cell ...

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  9. Stem cell - Wikipedia

    en.wikipedia.org/wiki/Stem_cell

    Adult stem cells, also called somatic (from Greek σωματικóς, "of the body") stem cells, are stem cells which maintain and repair the tissue in which they are found. [44] There are three known accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, usually from pelvic bones via ...

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