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Within a few weeks or days [3] Causes: Antipsychotic medication [1] Risk factors: Dehydration, agitation, catatonia [4] Diagnostic method: Based on symptoms in someone who has started on antipsychotics within the last month [2] Differential diagnosis: Heat stroke, malignant hyperthermia, serotonin syndrome, lethal catatonia [2] Treatment
In molecular biology, autophagy related 3 (Atg3) is the E2 enzyme for the LC3 lipidation process. [1] It is essential for autophagy . The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates.
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6.It is an E3 ubi autophagic cell death.ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles.
Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene. [ 5 ] [ 6 ] Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation.
The autophagy-inducible Beclin-1 complex [61] contains the proteins PIK3R4(p150), Atg14L and the class III phosphatidylinositol 3-phosphate kinase (PI(3)K) Vps34. [62] The active ULK and Beclin-1 complexes re-localize to the site of autophagosome initiation, the phagophore, where they both contribute to the activation of downstream autophagy ...
Macroautophagy is activated as early as 30 minutes into starvation and remains at high activity for at least 4–8 hours into starvation. If the starvation state persists for more than 10 hours, the cells switch to the selective form of autophagy, namely CMA, which is known to reach a plateau of maximal activation ~36 hours into fasting and ...
The substantia nigra is located in the ventral midbrain of each hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9 cell group that forms the nigrostriatal pathway that, by supplying dopamine to the striatum, relays information to the basal ganglia.
The headquarters of the NMS is located at 4-12 Nsamizi Road, in Entebbe, [4] a city on the northern shores of Lake Victoria, approximately 34 kilometres (21 mi), southwest of Kampala, the capital and its largest city. [5] The coordinates of the head office are 0°03'49.0"N, 32°28'13.0"E (Latitude:0.063611; Longitude:32.470278). [6]