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Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine.
The total body content of carnitine is about 20 grams (0.71 oz) in a person weighing 70 kilograms (150 lb), with nearly all of it contained within skeletal muscle cells. [3] Carnitine metabolizes at rates of about 400 μmol (65 mg) per day, an amount less than 1% of total body stores.
Nitrogen mustards (NMs) are cytotoxic organic compounds with the bis(2-chloroethyl)amino ((ClC 2 H 4) 2 NR) functional group. [1] Although originally produced as chemical warfare agents, [ 2 ] [ 3 ] they were the first chemotherapeutic agents for treatment of cancer. [ 4 ]
In molecular biology, autophagy related 3 (Atg3) is the E2 enzyme for the LC3 lipidation process. [1] It is essential for autophagy . The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates.
Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6.It is an E3 ubi autophagic cell death.ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles.
The headquarters of the NMS is located at 4-12 Nsamizi Road, in Entebbe, [4] a city on the northern shores of Lake Victoria, approximately 34 kilometres (21 mi), southwest of Kampala, the capital and its largest city. [5] The coordinates of the head office are 0°03'49.0"N, 32°28'13.0"E (Latitude:0.063611; Longitude:32.470278). [6]
3,4-Dimethylmethcathinone (3,4-DMMC) is a stimulant drug first reported in 2010 as a designer drug analogue of mephedrone, apparently produced in response to the banning of mephedrone, following its widespread abuse in many countries in Europe and around the world. [1] 3,4-DMMC has been seized as a designer drug in Australia. [2]
The myosin head is the part of the thick myofilament made up of myosin that acts in muscle contraction, by sliding over thin myofilaments of actin.Myosin is the major component of the thick filaments and most myosin molecules are composed of a head, neck, and tail domain; the myosin head binds to thin filamentous actin, and uses ATP hydrolysis to generate force and "walk" along the thin filament.