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With increasing clinical focus on dementia, there is likewise increasing interest in pharmacology in the development of drugs to halt, or slow the progression of dementia-related illness such as Alzheimer's Disease. Therefore, early and accurate diagnosis of dementia and staging can be essential to proper clinical care.
Similar to the NINCDS-ADRDA Alzheimer's Criteria are the DSM-IV-TR criteria published by the American Psychiatric Association. [3] At the same time the advances in functional neuroimaging techniques such as PET or SPECT that have already proven their utility to differentiate Alzheimer's disease from other possible causes, [4] have led to proposals of revision of the NINCDS-ADRDA criteria that ...
Diagnosis. One example [9] of a combination of biomarkers that can accurately diagnose AD is: Changes in brain atrophy patterns over time (measured by MRI) Levels of β-amyloid and tau (measured in CSF) A second approach to diagnosis is to extract the most pertinent information from MRI scans alone. [9]
A 2023 study published in the journal Acta Neuropathologica examined tissue from the brain and retina of 86 individuals and compared samples from donors with normal cognitive function to samples ...
The researchers sought to validate their tool by looking into the associations between nearly 400,000 participants’ Brain Care Score at the beginning of the UK Biobank study between 2006 and ...
Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. [1] There are two types of ARIA: ARIA-E and ARIA-H.
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